| Saltpeter | a burnt protector | Lavastorm Mountains | — |
| Saltpeter | a fire drake | Lavastorm Mountains | — |
| Saltpeter | a fire goblin scout | Lavastorm Mountains | — |
| Saltpeter | a fire imp | Lavastorm Mountains | — |
| Saltpeter | a cinder goblin warrior | Lavastorm Mountains | — |
| Saltpeter | a fire sprite | Lavastorm Mountains | — |
| Saltpeter | a lesser lavaspinner | Lavastorm Mountains | — |
| Scorpion Venom Gland | a broken skull scorpion | Gulf of Gunthak | — |
| Scrap of Dark Matter | Tialechaety Orrthemech | Abysmal Sea | — |
| Sealant | Saria Bromal | Plane of Knowledge | — |
| Sealant | Skelontorim Orrthemech | Abysmal Sea | — |
| Sealant | Tialechaety Orrthemech | Abysmal Sea | — |
| Sealant | Rylin Coil | Ak'Anon | — |
| Sealant | Geerlok Clockwork Merchant IV | Crescent Reach | — |
| Sealant | Ethrrian Drowius | East Freeport | — |
| Sealant | Eyunon Storius | East Freeport | — |
| Sealant | Trace the Tinker | Echo Caverns | — |
| Sealant | Blaylok Geerlok | Katta Castellum | — |
| Sealant | Engineer Beri | Plane of Knowledge | — |
| Sealant | Tabben Bromal | Plane of Knowledge | — |
| Sealant | Marchap Biddinight | Shadow Haven | — |
| Sealant | Bom Knotwood | Steamfont Mountains | — |
| Sealant | Tin Merchant V | The Overthere | — |
| Sealant | Mercator Acidinus (Tinkering Merchant) | The Overthere [RoS] | — |
| Sensate Reishi Lens | A mature sensate reishi | Paludal Caverns | — |
| Sensate Reishi Lens | A sensate reishi elder | Paludal Caverns | — |
| Sensate Reishi Lens | sensate reishi | Paludal Caverns | — |
| Serpent's Water | Merchant Tarrin | Plane of Knowledge | — |
| Serpent's Water | Ferin Lightfoot | Plane of Knowledge | — |
| Serpent's Water | Amile Pitt | Plane of Knowledge | — |
| Serpent's Water | Peras Glickon | Plane of Knowledge | — |
| Set of Vials | Engineer Beri | Plane of Knowledge | — |
| Set of Vials | Tabben Bromal | Plane of Knowledge | — |
| Set of Vials | Mercator Acidinus (Tinkering Merchant) | The Overthere [RoS] | — |
| Set of Vials | Rylin Coil | Ak'Anon | — |
| Set of Vials | Kwyllon Geerlok | Gulf of Gunthak | — |
| Set of Vials | Geerlok Clockwork Merchant IV | Crescent Reach | — |
| Sewing Contraption Parts | Engineer Beri | Plane of Knowledge | — |
| Sewing Contraption Parts | Tabben Bromal | Plane of Knowledge | — |
| Sewing Contraption Parts | Mercator Acidinus (Tinkering Merchant) | The Overthere [RoS] | — |
| Sewing Contraption Parts | Krizle Geerlok | Shadow Haven | — |
| Sewing Contraption Parts | Rylin Coil | Ak'Anon | — |
| Sewing Contraption Parts | Geerlok Clockwork Merchant IV | Crescent Reach | — |
| Sewing Contraption Parts | Zyleea Geerlok | Katta Castellum | — |
| Sharkskin Tubing | Tialechaety Orrthemech | Abysmal Sea | — |
| Sharkskin Tubing | Mercator Acidinus (Tinkering Merchant) | The Overthere [RoS] | — |
| Sharkskin Tubing | Tin Merchant V | The Overthere | — |
| Sharkskin Tubing | Bom Knotwood | Steamfont Mountains | — |
| Sharkskin Tubing | Marchap Biddinight | Shadow Haven | — |
| Sharkskin Tubing | Tabben Bromal | Plane of Knowledge | — |
