| Spider Silk | a sand crawler | Ruins of Takish Hiz | — |
| Spiderling Silk | a large wood spider | Toxxulia Forest | — |
| Spiderling Silk | a rock spiderling | Butcherblock Mountains | — |
| Spiderling Silk | a spiderling | Commonlands | — |
| Spiderling Silk | a crevice spiderling | Crescent Reach | — |
| Spiderling Silk | a diseased spiderling | Crescent Reach | — |
| Spiderling Silk | a hollows spiderling | Crescent Reach | — |
| Spiderling Silk | Canyon Queen | Crescent Reach | — |
| Spiderling Silk | The Hollows Widow | Crescent Reach | — |
| Spiderling Silk | a wooly spiderling | Everfrost Peaks | — |
| Spiderling Silk | a jungle spider | Feerrott | — |
| Spiderling Silk | a jungle spiderling | Feerrott | — |
| Spiderling Silk | a bonecrawler hatchling | Field of Bone | — |
| Spiderling Silk | a bonebinder hatchling | Field of Bone | — |
| Spiderling Silk | burynai-bane spider | Field of Bone | — |
| Spiderling Silk | a spiderling (Sometimes recluse spiders will release several spiderlings upon death.) | Goru`kar Mesa | — |
| Spiderling Silk | a widow hatchling | Greater Faydark (also see Kelethin) | — |
| Spiderling Silk | a spiderling | Kithicor Forest | — |
| Spiderling Silk | a spiderling | Lesser Faydark | — |
| Spiderling Silk | Spiderling Silk | Mistmoore Catacombs: Ritualistic Summoni | — |
| Spiderling Silk | Spider Silk | Mistmoore Catacombs: Ritualistic Summoni | — |
| Spiderling Silk | a large wood spider | Misty Thicket | — |
| Spiderling Silk | a spiderling | Misty Thicket | — |
| Spiderling Silk | an araneidae spiderling | Nektulos Forest | — |
| Spiderling Silk | a desert spiderling | Northern Desert of Ro | — |
| Spiderling Silk | a dune spiderling | Northern Desert of Ro | — |
| Spiderling Silk | a sludge spiderling | Qeynos Aqueducts | — |
| Spiderling Silk | a crab spiderling | Rathe Mountains (see also Gukta) | — |
| Spiderling Silk | a spiderling | Steamfont Mountains | — |
| Spiderling Silk | a spiderling | Toxxulia Forest | — |
| Spiderling Silk | a widow hatchling | Toxxulia Forest | — |
| Spiderling Silk | a spiderling | West Karana | — |
| Spinechill Ichor Vial | a jungle hunter | Cazic Thule | — |
| Spinechill Ichor Vial | a large hunter | Cazic Thule | — |
| Spinechill Ichor Vial | a jungle stalker | Cazic Thule | — |
| Spinechill Silk | a jungle hunter | Cazic Thule | — |
| Spinechill Silk | a large hunter | Cazic Thule | — |
| Spinechill Silk | a jungle stalker | Cazic Thule | — |
| Spool of Freetide Thread | Merchant Woad | Barren Coast | — |
| Sporali Skin | various darkroots | Direwind Cliffs | — |
| Sporali Skin | a sporeling (spawn only in the instanced Sporali Caverns for the Antraygus, the Sporali King event) | Sporali Caverns | — |
| Sporali Skin | a sporali protector | Undershore | — |
| Sporali Skin | a sporali sower | Undershore | — |
| Sporali Skin | a sporali defender | Corathus Creep | — |
| Sporali Skin | a sporali sower | Corathus Creep | — |
| Steel Barbs | Garald Samer | Abysmal Sea | — |
| Steel Barbs | Tonlyei Lyhin | Abysmal Sea | — |
| Steel Barbs | Sherin Matrick | Plane of Knowledge | — |
| Steel Barbs | Tailor Panya | Crescent Reach | — |
| Steel Barbs | Ilyon Olditia | East Freeport | — |
