| Slime Covered Planarian | Slime Covered Planarian | Deepest Guk: The Ancient Aqueducts | — |
| Slime Covered Planarian | Fresh Fish | Deepest Guk: The Accursed Sanctuary | — |
| Slime Covered Planarian | Fresh Fish | Deepest Guk: The Foreboding Prison | — |
| Slime Covered Planarian | Slime Covered Planarian | Deepest Guk: The Mushroom Grove | — |
| Slime Covered Planarian | Slime Covered Planarian | Mistmoore Catacombs: The Forlorn Caverns | — |
| Small Brick of Mithril | Merchant Niwiny | Kelethin (in Greater Faydark) | — |
| Small Brick of Mithril | Opal Leganyn | Northern Felwithe | — |
| Small Brick of Mithril | Tanalin Silverkale | Northern Felwithe | — |
| Small Clam | Arctic Mussels | Cobalt Scar [CoV] | — |
| Small Clam | Roots | Cobalt Scar | — |
| Small Clam | Roots | Siren's Grotto | — |
| Soda | Caden Zharik | Plane of Knowledge | — |
| Soda | Mercator Salonian (Baking Supplies) | The Overthere [RoS] | — |
| Soda | River Mudhands | Shadow Haven | — |
| Soda | Culkin Ironstove | Plane of Knowledge | — |
| Soda | Chef Denrun | Plane of Knowledge | — |
| Soda | Liviu | Goru`kar Mesa | — |
| Soda | Brewmaster Ishaq | Crescent Reach | — |
| Sonic Wolf Brain | a sonic wolf | Hollowshade Moor | — |
| Sop Bark | Bixie Berry Pie | Mines of Gloomingdeep | — |
| Sop Bark | Bixie Berry Pie | Warsliks Woods | — |
| Sop Bark | Emerald Palm Root | Thuliasaur Island | — |
| Speckled Toadstool | Fruit | Innothule Swamp | — |
| Steamfont Spring Water | Fruit | Steamfont Mountains | — |
| Steamfont Spring Water | a minotaur slaver | Steamfont Mountains | — |
| Steamfont Spring Water | Gorehound | Steamfont Mountains | — |
| Steamfont Spring Water | grikbar kobolds | Steamfont Mountains | — |
| Steaming Water | Fruit | Lavaspinner's Lair | — |
| Steaming Water | an iron warder | Stillmoon Temple | — |
| Steaming Water | a Stillmoon dirt tender | Stillmoon Temple | — |
| Steaming Water | Fruit | The Broodlands | — |
| Steaming Water | Fruit | The Accursed Nest | — |
| Steaming Water | a Flameweave scout | The Accursed Nest | — |
| Steaming Water | a Scorchclaw sneak | The Broodlands | — |
| Steaming Water | Fruit | Stillmoon Temple | — |
| Stone Beans | a dragorn armsman | Noble's Causeway | — |
| Stone Beans | a murkglider | Noble's Causeway | — |
| Stone Beans | a subjugated stoneworker | The Bloodfields | — |
| Stone Beans | a dragorn prelate | Noble's Causeway | — |
| Stone Beans | a dragorn guard | Noble's Causeway | — |
| Stone Snake Egg | a silverfin icefang | Corathus Creep | — |
| Stone Snake Egg | a Stonesnake rattler | Stoneroot Falls | — |
| Stone Snake Egg | a female Darkhollow redback | Stoneroot Falls | — |
| Stonefish | Fresh Fish | Jewel of Atiiki | — |
| Stonefish | Fresh Fish | Butcherblock Mountains | — |
| Stonewood Root | Rabbit Meat | Dranik's Scar | — |
| Stonewood Root | Roots | Wall of Slaughter | — |
| Stonewood Root | Pod of Water | The Bloodfields | — |
| Stonewood Root | Roots | Sewers of Dranik A | — |
| Stonewood Root | Roots | Ruined City of Dranik | — |
