| Spider Legs | an icy scavenger | Miragul's Menagerie: The Forgotten Waste | — |
| Spider Legs | a deathcrawler | Mistmoore Catacombs: Ritualistic Summoni | — |
| Spider Legs | poisoncrawler | Mistmoore Catacombs: Ritualistic Summoni | — |
| Spider Legs | a giant spider | Misty Thicket | — |
| Spider Legs | a giant wood spider | Misty Thicket | — |
| Spider Legs | an araneidae spiderling | Nektulos Forest | — |
| Spider Legs | giant spiders | North Karana | — |
| Spider Legs | a large spider | Qeynos Aqueducts | — |
| Spider Legs | yellow recluse | Steamfont Mountains | — |
| Spider Legs | a garden widow | Stone Hive | — |
| Spider Legs | a large wood spider | Toxxulia Forest | — |
| Spider Legs | widows (large and giant widow (spiders)) | Toxxulia Forest | — |
| Spider Legs | heart spiders | Upper Guk | — |
| Spider Legs | a mature lakeskater | Valdeholm | — |
| Spider Legs | giant spider | West Karana | — |
| Spider Legs | a carrion spider | East Karana | — |
| Spider Legs | a crag spider | East Karana | — |
| Spider Legs | a kerra spider | Erud's Crossing | — |
| Spider Legs | gigantic wooly spider | Everfrost Peaks | — |
| Spider Legs | wooly spiders (wooly spider, giant wooly spider) | Everfrost Peaks | — |
| Spire Mushroom | Spore Orchid | Stoneroot Falls | — |
| Spire Mushroom | Spore Orchid | Ruins of Illsalin | — |
| Spire Mushroom | Roots | Corathus Creep | — |
| Spire Mushroom | Spore Orchid | Temple of the Korlach | — |
| Spire Mushroom | Roots | Undershore | — |
| Splotched Sunfish | Diseased Fish | Direwind Cliffs | — |
| Sporali Cap | a sporali defender | Corathus Creep | — |
| Sporali Cap | a sporali defender | Sporali Caverns | — |
| Sporali Cap | a sporali protector | Sporali Caverns | — |
| Sporali Cap | a sporali sporeweaver | Corathus Creep | — |
| Sporali Cap | a sporali sower | Corathus Creep | — |
| Sporali Cap | a sporali harvester | Corathus Creep | — |
| Spore Orchid | Roots | Undershore | — |
| Spore Orchid | Spore Orchid | Temple of the Korlach | — |
| Spore Orchid | Spore Orchid | Stoneroot Falls | — |
| Spore Orchid | Spore Orchid | Ruins of Illsalin | — |
| Spore Orchid | Roots | Corathus Creep | — |
| Spotted Mushroom | various shrooms | Dawnshroud Peaks | — |
| Steppes Reptile Meat | a glade rattler | The Steppes | — |
| Steppes Reptile Meat | a crowned mamba | The Steppes | — |
| Steppes Reptile Meat | a timber lizard | The Steppes | — |
| Stone Snake Meat | Slither (Named Silverfin) | Corathus Creep | — |
| Stone Snake Meat | Slink (Named Silverfin) | Corathus Creep | — |
| Stone Snake Meat | a female Darkhollow snake | Stoneroot Falls | — |
| Stone Snake Meat | a silverfin icefang | Corathus Creep | — |
| Storm Salmon | Fresh Fish | Plane of Storms | — |
| Strange Fish | Fresh Fish | Ethernere Tainted West Karana | — |
| Strange Fish | Strange Fish | The Dead Hills | — |
| Sugarcane | Culkin Ironstove | Plane of Knowledge | — |
| Sugarcane | Kriss T'Bel | Neriak Fourth Gate | — |
